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China Journal of Chinese Materia Medica ; (24): 832-845, 2002.
Article in Chinese | WPRIM | ID: wpr-271798

ABSTRACT

<p><b>OBJECTIVE</b>To make a solid form of Angelica Sinensis essential oil by preparing its inclusion compound with beta-cyclodextrin and evaluate the inclusion rate, dissolution rate and liberating rate of this complex.</p><p><b>METHOD</b>GC-MS, X-ray diffraction and thin-layer chromatography were applied to characterize the essential oil and the inclusion compound.</p><p><b>RESULT</b>The inclusion compound was shown to form a new phase by X-ray diffraction analysis. GC-MS and TLC check-up corroborated the composition of the free oil and the inclusion oil remaining the same.</p><p><b>CONCLUSION</b>The results showed Angelica Sinensis essential oil was more stable with beta-cyclodextrin inclusion. The preparation of this inclusion compound has advantages in limited amount, long time effect, easily preserved and convenient administration as a new dosage form.</p>


Subject(s)
Angelica sinensis , Chemistry , Cyclodextrins , Dosage Forms , Drug Carriers , Drug Stability , Oils, Volatile , Plant Roots , Chemistry , Plants, Medicinal , Chemistry , Solubility , Technology, Pharmaceutical , Methods , X-Ray Diffraction , beta-Cyclodextrins
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